Accession Number:

ADA181691

Title:

Synthesis of Nucleoside Mono- and Dialdehydes as Antiviral Agents.

Descriptive Note:

Annual rept. 15 Nov 85-14 Nov 86,

Corporate Author:

ROCHESTER INST OF TECH NY

Personal Author(s):

Report Date:

1986-12-15

Pagination or Media Count:

20.0

Abstract:

Seven nucleoside 2, 3 -dialdehydes were synthesized by periodic oxidation of inosine, 6-methylmercaptopurine riboside, thymine riboside, guanosine, 5-fluoro-5deoxyadenosine, 8-bromoadenosine, and N6, N6-dimethylaminopurine riboside, respectively. The resultant nucleoside dialdehydes, as well as the intermediate 5-fluoro-5deoxyadenosine, were submitted to the USAMRIID antiviral screening program. Keywords Antiviral agents.

Subject Categories:

  • Pharmacology
  • Organic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE