Therapeutic Approaches to the Treatment of Botulism
Annual rept. 1 Sep 1985-31 Jul 1986
JEFFERSON MEDICAL COLL PHILADELPHIA PADEPT OF MEDICINE
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In vitro experiments have been done on isolated phrenic nerve- hemidiaphragm preparations. The purpose of the experiments was to evaluate aminopyridines as putative therapeutic agents in the treatment of botulism and to develop monoclonal antibodies that would neutralize botulinum toxin and tetanus toxin. The work demonstrates that aminopyridines are active against type A botulinum toxin. Research on antibodies is still in progress. Keywords Antidotes Botulism Food poisoning.