The Effects of Diisopropyl Phosphorogluoridate (DFP) of Inter-Response Time and Circadian Patterns of Lever Pressing in Rats,
WALTER REED ARMY INST OF RESEARCH WASHINGTON DC NEUROPHARMACOLOGY BRANCH
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Rats were injected with saline, 1.0 mgkg or 2.6 mgkg of diisopropyl phosphorofluoridate DFP. Three days later the animals were placed in cages in which they could press a lever to obtain their entire daily ration of food. The time of day at which responses occurred and the time between successive responses were recorded over a six day period to determine the circadian pattern of lever-pressing and the distribution of inter-response times IRTS. The saline injected rats exhibited a normal nocturnal pattern of feeding, while both DFP treated groups exhibited a significantly greater tendency to eat during the day. Analysis of the IRT distributions of the three groups showed a different pattern of results. The saline and 1.0 mgkg DFP groups produced nearly identical IRT distributions, while the 2.6 mgkg group produced an IRT distribution which was marked by significant increases in the interquartile range and median IRT. Keywords Diisopropy, Phosphorofluoridate, Fluoridates, Phosphorus compounds, Circadian, Activity, In response, Time, Response, Topography, Rats.
- Anatomy and Physiology