Accession Number:

ADA181549

Title:

The Effects on Pilot Performance of Antiemetic Drugs Administered Singly and in Combination

Descriptive Note:

Final rept. Feb 83-May 85

Corporate Author:

ILLINOIS UNIV AT URBANA-CHAMPAIGN SAVOYINST OF AVIATION

Report Date:

1987-03-01

Pagination or Media Count:

98.0

Abstract:

Four experiments were conducted to evaluate the effects on human performance of alcohol and antiemetic drugs. In Experiment I, the effects on pilot performance of 4 blood alcohol levels BAL were investigated to determine the sensitivity of the methodology. Experiment II evaluated the effects on pilot performance in a flight simulator of prescribed dosages of thiethylperazine 10 mg, promethazine hydrochloride 25 mg, cimetidine 300 mg, and a placebo control. Two tasks, a two-dimensional tracking task which is part of an instrument landing system ILS approach and the Sternberg Memory Search task, were used to generate pilot performance data. In Experiment III the effects of combinations of antiemetic drugs were investigated. Two additional flight task dependent variables, turning rate control while straight and level and while turning were added. Experiment IV evaluated the effects of alcohol on pilot performance the results were compared with the performance degradations resulting from combinations of antiemetic drugs. The results indicated that 0.12 percent BAL produced a decrement in pilot simulator instrument flight performance. In comparison with the PTC effects, the high BAL produced a relatively larger performance decrement than the PTC combination. Keywords Flight simulation, Pilot studies, Intoxication.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE