Accession Number:

ADA181041

Title:

Effects of Atropine, 2-PAM, or Pyridostigmine in Euvolemic or Hemorrhagic Conscious Swine.

Descriptive Note:

Rept. for 1984-1987,

Corporate Author:

LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Report Date:

1987-04-01

Pagination or Media Count:

26.0

Abstract:

We investigated the effects of atropine, pralidoxime chloride 2-PAM, or pyridostigmine on the physiological and metabolic responses to hemorrhagic hypotension in conscious swine. All treatments were evaluated in euvolemic and hemorrhaged animals 36 ml of bloodkgover one hour. Hemorrhage reduced blood pressure by 58 mmHg and decreased plasma acetylcholinesterase AChE activity by 18 in the control animals n6. Atropine injection increased heart rate similarly in hemorrhaged n6 and euvolemic n6 animals. Blood pressure was also transiently elevated following atropine administration. Injection of 2-PAM acutely elevated the levels of plasma lactate and plasma AChE, but values were similar to those in the untreated animals within 15 min in both euvolemic n7 and hemorrhaged n7 animals. Treatment with pyridostigmine for 3 days reduced plasma AChE by 37 and red blood cell AChE by 35 n12. Pretreatment with pridostigmine had no effect on any of the responses to hemorrhage. Posthemorrhage treatment with atropine or 2-PAM or pretreatment with pyridostigmine had no detrimental effects on the physiological or metabolic responses to moderate hemorrhage in conscious swine. Keywords Wounds and injuries Trauma.

Subject Categories:

  • Pharmacology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE