Accession Number:

ADA180934

Title:

Triazolam - Performance Side Effects: Vestibular, Musculoskeletal, and Complex Performance Tests.

Descriptive Note:

Interim rept.,

Corporate Author:

NAVAL AEROSPACE MEDICAL RESEARCH LAB PENSACOLA FL

Report Date:

1987-03-04

Pagination or Media Count:

28.0

Abstract:

Transient insomnia preceding or during intense military aviation operations has, in some cases, been treated by short-acting benzodiazepines like temazepam or triazolam. This study evaluated selected physiological and performance side effects of triazolam 0.25 mg administered to nine men and one woman. Each subject completed drug and placebo testing, which started at one and eight hours following drug administration. Testing included measures of balance, fine motor movement, two-dimensional tracking, tilt table, tri-service performance assessment battery, pulmonary function, bike ergometer, and strengthendurance. This dose of triazolam produced no significant change in any of the tests with the exception of the balance tests. This study did not identify any significant performance side effects that would disqualify this agent for acute short-term use against insomnia sometimes encountered in the military aviation environment. Keywords Sleep deprivation Aerospace medicine.

Subject Categories:

  • Stress Physiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE