Accession Number:

ADA180858

Title:

Evidence for an Involvement of NMDA (N-methyl-D-aspartate) Receptor Mechanisms in Experience-Dependent Plasticity of Kitten Striate Cortex.

Descriptive Note:

Technical rept.,

Corporate Author:

BROWN UNIV PROVIDENCE RI CENTER FOR NEURAL SCIENCE

Personal Author(s):

Report Date:

1987-05-20

Pagination or Media Count:

19.0

Abstract:

Intracortical infusion of the NMDA N-methyl-D-aspartate receptor blocker 2-amino-5-phosphonovaleric acid APV renders kitten striate cortex resistant to the effects of monocular deprivation. In addition, one week of APV treatment produces a striking loss of orientation selectivity in area 17. These data support the hypothesis that crucial variables for the expression of activity dependent synaptic modifications are a critical level of postsynaptic activation and calcium entry through gates linked to NMDA receptors.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE