Evidence for an Involvement of NMDA (N-methyl-D-aspartate) Receptor Mechanisms in Experience-Dependent Plasticity of Kitten Striate Cortex.
BROWN UNIV PROVIDENCE RI CENTER FOR NEURAL SCIENCE
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Intracortical infusion of the NMDA N-methyl-D-aspartate receptor blocker 2-amino-5-phosphonovaleric acid APV renders kitten striate cortex resistant to the effects of monocular deprivation. In addition, one week of APV treatment produces a striking loss of orientation selectivity in area 17. These data support the hypothesis that crucial variables for the expression of activity dependent synaptic modifications are a critical level of postsynaptic activation and calcium entry through gates linked to NMDA receptors.
- Anatomy and Physiology