Accession Number:
ADA180858
Title:
Evidence for an Involvement of NMDA (N-methyl-D-aspartate) Receptor Mechanisms in Experience-Dependent Plasticity of Kitten Striate Cortex.
Descriptive Note:
Technical rept.,
Corporate Author:
BROWN UNIV PROVIDENCE RI CENTER FOR NEURAL SCIENCE
Personal Author(s):
Report Date:
1987-05-20
Pagination or Media Count:
19.0
Abstract:
Intracortical infusion of the NMDA N-methyl-D-aspartate receptor blocker 2-amino-5-phosphonovaleric acid APV renders kitten striate cortex resistant to the effects of monocular deprivation. In addition, one week of APV treatment produces a striking loss of orientation selectivity in area 17. These data support the hypothesis that crucial variables for the expression of activity dependent synaptic modifications are a critical level of postsynaptic activation and calcium entry through gates linked to NMDA receptors.
Descriptors:
Subject Categories:
- Biochemistry
- Anatomy and Physiology