Cardiopulmonary Effects of Stressful Exercise at Altitude (4,000 FT) of Individuals with Sickle Cell Trait (HbAS or SCT).
Annual rept. 1 Apr 85-30 Apr 86,
WILLIAM BEAUMONT ARMY MEDICAL CENTER EL PASO TX
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Controversy persists regarding the risks assumed by individuals with SCT while engaged in activities that would involve a greater likelihood of exposure to hypoxic environments and other stress situations such as performing strenuous exercise especially at altitude. The present study was designed to evaluate the role of a hypoxic stimulus simulated altitude of 2300m on the interactions of Hemoglobin S HbS, sickling S, and acute strenuous physical exertion in SCT volunteers compared to controls. The study population included healthy black make basic recruits with well characterized SCT HbAS n11 and a comparable control group HbAA n11. Utilizing current physiological methodology, we were unable to detect any subtle physiologic differences between the two groups. The consistently lower haptoglobin levels observed in SCT subjects compared to controls may reflect a chronic low grade, sub-clinical hemolytic state in these individuals. Increasing environmental hypoxia up to a simulated altitude of 3000m did not significantly increase percent sickling in peripheral venous blood at rest. Keywords Blood diseases Blood chemistry ExercisePhysiology StressPhysiology.
- Stress Physiology
- Medicine and Medical Research