Stability Studies of Bis(Pyridiniumaldoxime) Reactivators of Organophosphate-Inhibited Acetylcholinesterase,
WALTER REED ARMY INST OF RESEARCH WASHINGTON DC
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Relative stability studies of three organophosphate-inhibited acetylcholinesterase reactivators, Hl-6, MMB-4, TMB-4 were carried out by semiquantitative TLC and NMR methods. TMB-4 appears to be most, and Hl-6 the least stable of the three compounds. The stability of these reactivators decreases with increasing pH. TMB-4 was stable under both neutral and basic conditions at room temperature. Deuterium exchange of the methylene protons of MMB-4 in D2O and of the protons at the 2- and 6- positions of the pyridinum ring of TMB-4 IN NaODD2O were observed. Reprints.
- Organic Chemistry