An Investigation of the Causes of the Blood Platelet 'Storage Lesion'.
Annual rept. Feb 85-Jan 86, Final rept. 1 Feb 84-31 Jan 86,
NORTH CAROLINA UNIV AT CHAPEL HILL
Pagination or Media Count:
The role of thrombin in the platelet storage lesion has been examined and identified. We have shown that citrate formulations do not completely block the generation of thrombin during the preparation and storage of platelet concentrates. There is presented evidence that stored platelets and residual free calcium ions provide a support mechanism for formation of the prothrombinase complex in platelet concentrates. The addition of specific thrombin inhibitors and general inhibitors and general inhibitors of platelet activation to citrate anticoagulants for platelet concentrates has resulted in remarkably improved storage characteristics as assessed by in vitro markers. We believe that these studies provide a sound basis for the further investigation of the effectiveness of novel anticoagulants for use in the preparation and storage of platelet concentrates. Keywords Human blood donors Fibrinopeptide A Antithrombin III.
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