Evaluation of Drugs for Prevention of Hyperthermia in Rats Exposed to Microwave Irradiation.
Final rept. 1983-1985,
NAVAL AEROSPACE MEDICAL RESEARCH LAB PENSACOLA FL
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The objective of this study was to determine the effectiveness of two antipyretic drugs, indomethacin and dihydrotachysterol, in the prevention of microwave-induced hyperthermia in rats. Indomethacin has been proven effective in reducing fever of pyrogenic origin. Dihydrotachysterol DHT is effective in increasing survival of rats during heat stress. After being acclimated to restraint in an acrylic cone-shaped holder and to the presence of a colonic temperature probe each rat was subjected to a series of body temperature measurements under various drug and microwave conditions. Pretreatment with both drugs consisted of single and multiple injections prior to microwave exposure. Multiple does of DHT caused a progressive fall in baseline body temperature, but did not affect the relative increase in temperatures due to microwave irradiation. Single injection procedures did not reduce temperature elevation due to microwave irradiation. Neither indomethacin nor DHT were found to ameliorate microwave-induced hyperthermia. Keywords Radiation tolerance.