Accession Number:

ADA179988

Title:

Heat Exchange After Atropine and Pralidoxime Administration

Descriptive Note:

Technical rept.,

Corporate Author:

ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA

Report Date:

1986-12-01

Pagination or Media Count:

28.0

Abstract:

This report summarizes a tightly controlled laboratory study in which the effects of intramuscular saline control, atropine 2 mg, andor pralidoxime 600 mg on heat exchange were evaluated in four healthy males during seated, cycle exercise in a temperate environment. Esophageal, reactal, and mean skin temperature, and chest and forearm sweating were continuously measured. Skin blood flow FBF from the forearm was measured twice each minute by venous occlusion plethysmography. Whole body sweating was calculated from weight changes. Atropine injection, decreased eccrine sweating and elevated esophageal and skin temperatures. Heart rate and FBF were higher after atropine. Pralidoxime, in general, did not affect the core and skin temperature responses to the exercise differently from control however, a slightly elevated FBF compensated for the reduction in whole body sweating. The combination of the drugs resulted in significantly higher esophageal and skin temperatures than atropine alone. The thermoregulatory disadvantage of inhibited sweating by atropine was partially compensated for the by enhanced skin blood flow in this environment. Pralidoxime was shown to decrease whole body sweating by a mechanism as yet unexplained.

Subject Categories:

  • Medicine and Medical Research
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE