Efficacy and Mode of Action of Immune Response Modifying Compounds against Alphaviruses and Flaviviruses.
Annual rept. 1 Jan-31 Dec 86,
MEDICAL COLL OF PENNSYLVANIA PHILADELPHIA DEPT OF MICROBIOLOGY AND IMMUNOLOGY
Pagination or Media Count:
Several immunomodulators were effective against infection of adult mice with herpes simplex virus type 2 HSV-2, Venezualean equine encepalitis alphavirus VEE, Banzi flavivirus or Caraparu bunyavirus. Similar effectiveness was found among the various immunodulators, although the viruses did differ in sensitivity. Infection with Banzi virus was the most sensitive, while infection with Caraparu virus was least sensitive to treatment with immunomodulators. Greatest antiviral protection was observed with C. parvum, alpha interferon, and the synthetic immunomodulators MVE-2, CL246,738 and amplign. Moderate protection was produced with gamma interferon and various microbially derived cell wall materials. Greatest effects with the immunomodulators were observed with prophylactic treatment, but early or repeated therapeutic treatment with such drugs as CL246,738, ampligen and alpha or gamma interferon was also partially effective. Thus, a variety of chemically diverse agents can produce broad spectrum antiviral protection. Immunomodulator induced alterations in nonspecific immunity may be involved in the protection. Many of the compounds induced NK cell activity and activated macrophages. A common mechanism for the antiviral action, however, has yet to be established. Keywords Antiviral agents.
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