Cloning of Acetylcholinesterase Gene in a Microbial Vector.
Annual rept. 1 May 82-31 Jan 83,
INVERESK RESEARCH INTERNATIONAL LTD MUSSELBURGH (SCOTLAND)
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Techniques to distinguish between the activities of human acetylcholinesterase and pseudocholinesterase have been developed. Human neuroblastoma cell lines have been shown to synthesize human acetylcholinesterase and the level of enzyme within these cells can be induced by treatment of cells with sodium butyrate or dibutyryl cAMP. These cell lines should be suitable as a source of mRNA for the cloning of the human gene into E. coli. Keywords Genetics Cholinesterases.
- Genetic Engineering and Molecular Biology