Effect of Atropine and 2-PAM Chloride on Vision and Performance.
Annual rept. 1 Sep 84-31 Aug 85, Final/Annual rept. 1 Sep 83-31 May 86,
MEDICAL RESEARCH INST OF SAN FRANCISCO CA
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The effects on human volunteers of atropine in doses of 2 and 4 mg70 kg body weight, 2-PAM CL Chlorine in doses of 600 and 1200 mg70 kg and all possible combinations of these two anticholinergic drugs are described on a tank tracking simulator task BLASER, and on a battery of visual functions, and on selected cardiovascular measures as well as on cognitivememory function. The majority of effects of the combination doses can be predicted from the atropine results. 2-PAM CL has no effect on any measured function. The doses containing 4 mg atropine produced significant loss of tracking performance with peak loss occuring around 3 hours after injection. Signs of recovery were noted at 4 hours. The lower doses of atropine alone and in combination with 2-PAM CL had no effect on tracking. Atropine alone and in combination with 2-PAM CL produced long lasting visual side-effects. A small but significant potentiation of effects occurred for the high dose combination on several peripheral visual functions and some cardiovascular measures. Atropine 4 mg was also found to affect retinal color mechanisms. No effect was found on memorycognitive function. The time course of effects are delineated for each measure. Cardiovascular measures have a rapid time course, tracking performance loss shows an intermediate time course and the peripheral visual functions show a very prolonged time course.