Direct Assessment of Synaptic Modification Rules.
Final rept. Jun 83-May 86,
VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE
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This research has related experimental data on synaptic modification to the development of algebraic synaptic modification rules. The experimental findings support the following ideas 1 There is a threshold for either synaptic potentiation or depression in dentate hyrus cells 2 both potentiation and depression are equally long-term and are thus treated equally in the synaptic modification rule equation 3 associativity means co-activity between pre- and postsynaptic elements 4 the rate of change with successive conditioning trains is consistent with a steep sigmoid or binary process rather than a linear process. The results suggest that excitatory synaptic potentiation might occur via three mechanisms more transmitter release, more conductance through the spine stems of potentiated synapses.
- Anatomy and Physiology