Phosphoprotein Regulation of Synaptic Reactivity: Enhancement and Control of a Molecular Gating Mechanism.
Final technical rept. 30 Sep 83-29 Sep 86,
NORTHWESTERN UNIV EVANSTON IL CRESAP NEUROSCIENCE LAB
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This research is focussed on the role of molecular switches in brain which regulate synaptic reactivity. We have indentified a 47,000 mol wt phosponprotein and its kinase C which play a pivotal role in this regulation. We have enhanced communication among nerve cells studied electrophysiologically by activation of this kinase. In the proposed research we specifically manipulate this brain phosphoprotein with novel kinase activating agents. In a new initiative, both the kinase and the F1 substrate will be cloned with the goal of enchancing synaptic reactivity by regulating the expression of proteins that play a pivotal role in this process. Keywords Synapse Plasticity Phosphorylation Fatty acids Lontophopersis.