Accession Number:

ADA179431

Title:

Pharmacological Sparing of Protein and Glucose in Burn Injury and/or Sepsis.

Descriptive Note:

Annual summary rept. 24 Oct 83-23 Oct 84,

Corporate Author:

TEXAS UNIV MEDICAL BRANCH AT GALVESTON

Personal Author(s):

Report Date:

1985-01-29

Pagination or Media Count:

52.0

Abstract:

We have assessed the role of glucagon and sympathetic nervous system SNS activity on glucose and palmitate kinetics and oxidation in the conscious dog infused with live E. coli bacteria. These studies lead us to conclude that the lowering of glucagon concentration should have an important effect in reducing gluconeogenesis, and thus protein wasting. Manipulation of the sympathetic nervous system to enhance the mobilization of lipid, on the other hand, does not seem likely to be fruitful since there are already ample amounts of fatty acids available as energy substrates. Future studies will therefore focus entirely on minimizing protein breakdown directly and via suppression of gluconeogensis, and adrenergic blockade will not be pursued.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE