A Multidisciplinary Study of Ciguatoxin and Related Low Molecular Weight Toxins from Marine Source
Annual rept. 15 Aug 1985-14 Aug 1986
HAWAII UNIV AT MANOA HONOLULU DEPT OF PHARMACOLOGY
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The work in this report deals with the isolation and purification of ciguatoxin from ciguateric fish, the pharmacology and toxicology of ciguatoxin and other toxins extracted from various assays and progress made on a system for detection of ciguateric fish flesh. Ciguatoxin has been isolated from livers and viscera of eels obtained from Pacific Islands where ciguatera is endemic. Evaluation of the pharmacology and toxicology has been both in vitro and in vivo systems but has been hampered by a shortage of purified toxins. The immunological stick method of assaying of ciguatera in fish has yielded interesting and promising results. Work on all of these aspects of ciguatera toxicity and toxicity to other marine toxins is proceeding at an accelerated pace.