Accession Number:

ADA179119

Title:

Chemical Preparation Laboratory for IND Candidate Compounds.

Descriptive Note:

Annual rept. 17 Jan 86-16 Jan 87,

Corporate Author:

PHARM-ECO LABS INC SIMI VALLEY CA

Personal Author(s):

Report Date:

1987-01-30

Pagination or Media Count:

50.0

Abstract:

During the reporting period eleven compounds were prepared and submitted 1-beta-D-Ribofuranosy1-1,2,4-triazole-3-carboxamidine hydrochloride methyl-4-chloro- 5-2,4-dichloropheny1-1Hpyrazole-3-carboxylate 3-deazauridine 1-beta-D-ribofuranosy1-1,2,4-triazole-3-carboxamide Ribavirin 4-imino-pyrazolo3,4-D-thiazine-67Hthione 7-carbamoy1-1-beta-D-ribofuranosylimidazo1,2-Bpyrazol-6-y1-methylsulfone Lycoricidine triacetate 2-beta-d-ribofuranoysl-selenazo-4-carboxamide 2,3,5 -tri-0-acetyl-2-beta-D-ribofuranosyl-selenazo-4-carboxamide 4H-r, 1H-trans, 2H-cis, 10bH-trans, 1-2-tetrahydropyranyloxy 2-hydroxy-8,9-methylenedioxy-1,2,4a,10b-tetrahydro-65Hphenanthridone 4aH-r, 1H-trans, 2H-cis, 10bH-trans-1,2-Dihydroxy-8,9-methylenedioxy-1,2,4a,10b-tetrahydro-5Hphenanthridone. Three compounds remain under investigation 3-Deazaguanine Combretastation. Keywords Nucleosides, antivirals, selenazoles, triazoles, alkaloids, formycin, nucleosides, ribavirin.

Subject Categories:

  • Organic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE