Accession Number:

ADA179095

Title:

Studies of the Biological and Molecular Basis of the Inhibition of Activity of Phagocytic Cells by Anthrax Toxin

Descriptive Note:

Annual rept. 30 Sep 1984-30 Sep 1985

Corporate Author:

VIRGINIA UNIV CHARLOTTESVILLE DIV OF INFECTIOUS DISEASES

Report Date:

1986-02-01

Pagination or Media Count:

25.0

Abstract:

Pretreatment with anthrax toxin inhibits priming of polymorphonuclear neutrophils by lipopolysaccharide or muramyl dipeptide, resulting in reduction in release of superoxide anion when the cells are stimulated with chemotactic peptide. The resulting attenuation of critical antibacterial activities of neutrophils may represent an important mechanism of virulence in Bacillus anthracis. Keywords Phagocytes, Superoxide Anion, Lipopolysaccharide Bacterial toxins.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE