Accession Number:

ADA179028

Title:

Pressure Studies of Protein Dynamics.

Descriptive Note:

Technical rept. 1 Mar-28 Feb 87,

Corporate Author:

ILLINOIS UNIV AT URBANA DEPT OF PHYSICS

Personal Author(s):

Report Date:

1987-02-20

Pagination or Media Count:

87.0

Abstract:

The relation between dynamic structure and function of proteins is investigated. Protein dynamics are studied by observing the phenomena induced by flash photolysis using near ultraviolet, optical, and infrared spectroscopies over wide ranges in temperature 60-300K, time 50ns-Iks, and, pressure 0.1-200MPa. Initially we study a simple biomolecular reaction - carbon monoxide binding to myoglobin. Previous work over wide ranges in temperature and time has been crucial to developing models of protein dynamics. We developed a hierarchical model of protein dynamics which promises to contribute to understanding both biomolecular reactions and the physics of amorphous solids and glasses. The combined pressure and temperature experiments will test various features of the hierarchical model including the glass-like properties of proteins. Keywords Proteinquake, flash photolysis, spectroscopic markers, ligand binding.

Subject Categories:

  • Biochemistry
  • Atomic and Molecular Physics and Spectroscopy

Distribution Statement:

APPROVED FOR PUBLIC RELEASE