Accession Number:

ADA177153

Title:

Pathogenesis of Cell Injury by Rickettsia conorii

Descriptive Note:

Annual rept. 11 Apr 1985-6 Aug 1986; Final rept. 11 Apr 1983-6 Aug 1986

Corporate Author:

NORTH CAROLINA UNIV AT CHAPEL HILL

Personal Author(s):

Report Date:

1986-11-26

Pagination or Media Count:

59.0

Abstract:

This work was undertaken to determine the pathogenic mechanism by which Rickettsia conorii causes disease. R. conorii, an organism that has been neglected in spite of its widespread distribution and pathogenic qualities, was studied in human subjects, animal models, and in vitro. The purpose of the work is to elucidate the pathology of boutonneuse fever and the pathogenic mechanisms which might be blocked therapeutically or prophylactically by examination for presence and severity of specific pathologic features. The study evaluated the following cutaneous necrosis, vasculitis, thrombosis, and dermal edema. The predominant leukocytes were lymphocytes and macrophages immunofluorescent Rickettsia conorii were demonstrated.

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE