Pathogenesis of Cell Injury by Rickettsia conorii
Annual rept. 11 Apr 1985-6 Aug 1986; Final rept. 11 Apr 1983-6 Aug 1986
NORTH CAROLINA UNIV AT CHAPEL HILL
Pagination or Media Count:
This work was undertaken to determine the pathogenic mechanism by which Rickettsia conorii causes disease. R. conorii, an organism that has been neglected in spite of its widespread distribution and pathogenic qualities, was studied in human subjects, animal models, and in vitro. The purpose of the work is to elucidate the pathology of boutonneuse fever and the pathogenic mechanisms which might be blocked therapeutically or prophylactically by examination for presence and severity of specific pathologic features. The study evaluated the following cutaneous necrosis, vasculitis, thrombosis, and dermal edema. The predominant leukocytes were lymphocytes and macrophages immunofluorescent Rickettsia conorii were demonstrated.
- Medicine and Medical Research