Immunomodulation with Synthetic Molecules: Mechanisms of Actions and Effects on Macrophages.
Final rept. Nov 82-Oct 86,
INSTITUTE FOR MEDICAL RESEARCH SAN JOSE CA
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Immunoenhancing drugs were studied both for their general effects on host immunity and their effects on immune interactions with microbial infections. These studies focused preferentially on defined single molecules with immunomodulating properties, both wholly synthetic molecules muramayl dipeptide was the prototype and those produced by recombinant DNA techniques gamma interferon was the prototype. Fungi were the microbes of interest. The effects of immunomodulators on fungicidal activity of tissue microphages from different anatomic compartments pulmonary, peritoneal were compared. We demonstrated that polymorphonuclear leukocytes PMN can be activated in vivo for enhanced fungicidal activity as a byproduct of an immunological or an inflammatory reaction, and that this could be reproduced with lymphokines or other immunomodulators. The mechanism of PMN activation was defined with respect to the oxidative mechanisms involved.
- DEOXYRIBONUCLEIC ACIDS
- INFECTIOUS DISEASES
- IN VIVO ANALYSIS
- FUNGUS DISEASES
- POLYMORPHONUCLEAR LEUKOCYTES
- RETICULOENDOTHELIAL SYSTEM
- Medicine and Medical Research