Accession Number:

ADA175840

Title:

Severity Levels and Symptoms Complexes for Acute Radiation Sickness -- Description and Quantification

Descriptive Note:

Technical rept. 6 Jan 1984-31 Mar 1985

Corporate Author:

PACIFIC-SIERRA RESEARCH CORP LOS ANGELES CA

Personal Author(s):

Report Date:

1985-11-30

Pagination or Media Count:

81.0

Abstract:

This report develops a descriptivequantifying structure to express and gauge the severity of symptoms, forms Symptom complexes, and construct a dosetime map of the symptom squealed following prompt ionizing radiation exposure and injury in humans. Radiation doses in the range of 75 to 4500 rads and postexposure time up to 6 weeks are considered. Symptom severity levels, ranging from level 1 no apparent effect to level 5 maximum severity, are defined for each of 6 symptoms categories including 1 upper gastrointestinal distress, 2 lower GI distress, 3 fatigability and weakness, 4 hypotension, 5 infection, bleeding, and fever, and 6 fluid loss and electrolyte imbalance. Temporal profiles of symptom severity are developed for the 6 symptom categories as well as for the symptom complexes formed by combining each symptom category according to severity level along postexposure time. About 100 different symptom complexes cover the dose and time ranges of interest. A dosetime mapping of the symptom complexes was used to select 30 to 40 of the most important ones. Those were included on U.S. Army questionnaires designed to obtain personnel judgments of task performance under various degress of debilitation. The incidence of upper GI distress, lower GI distress, fatigability and weakness, and early diarrhea are estimated based on probit and logit analyses of medical data.

Subject Categories:

  • Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE