Mechanisms of Resistance in Microbial Spores.
Final technical rept. 14 Mar 83-13 Sep 86,
MICHIGAN STATE UNIV EAST LANSING DEPT OF MICROBIOLOGY AND PUBLIC HEALTH
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Bacterial spores possess extraordinary resistance against destruction by heat and other deleterious agents, so extreme safeguards must be taken to prevent spore-caused infections, food spoilage and food poisoning. A determination of the physicochemical bases and physiological mechanisms accounting for spore resistance is the goal of this project. The rationale of approach is to employ biophysical probes that are invasive but not destructive to the cellular and molecular configurations conferring resistance in intact spores. Genetic, biochemical and microbiological techniques are also employed. The project involves collaboration by teams of investigators at two universities. Substantial progress has been accomplished during the contract period, with a number of articles published or in press.