Conduct Studies of Supercritical Fluids Relevant to Chromatography and Mass Spectrometry.
Final rept. 1 Oct 83-30 Sep 86,
BATTELLE PACIFIC NORTHWEST LAB RICHLAND WA
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The main thrust of the research was the study of supercritical fluids as applied to chromatography and mass spectrometry. The most important results obtained were 1 the ability to qualitatively predict and study the effects of solute retention using polar modifiers to enhance separations and decrease retention times 2 the capability of rapid pressure programming in capillary SFC which greatly reduced separation times 3 the continued evolution and improvement in design and implementation of SFC-MS, direct fluid injection-MS interfaces and capillary flow restrictors leading to enhanced detection capabilities and 4 the understanding of the effects of fluid density on the enthalpy of solute transfer in SFC. These results have allowed the chemical tailoring of mobile phase interactions between the solvent and solute for enhanced separations. Most importantly the results on interface design in SFC-MS and DFI-MS allow these techniques to assume an important role in the characterization and analysis of thermally labile, nonvolatile components, which were formally intractable by other methods.
- Industrial Chemistry and Chemical Processing
- Physical Chemistry