Interaction of Phenyldichloroarsine with Biological Molecules
Final technical rept. 1 May 1985-1 May 1986
LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
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Carbon 14 -Phenyldichloroarsine PDA was used to study the binding of PDA to erythrocytes and stroma-free hemoglobin. Natural abundance Carbon 13- nuclear magnetic resonance spectroscopy Carbon 13-NMR was used to study the binding of DPA to glutathione, meso-2,3-dimercaptossuccinic acid DMSA, and British anti-Lewisite BAL. The results clearly show that PDA penetrates the red cell and is contained within. Apparently hemoglobin is not the internal sulfhydryl-containing species that holds the DPA, glutathione appears to be a better candidate. Carbon 13-NMR is a promising tool for investigating DPA complexes.
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