Accession Number:

ADA175296

Title:

Interaction of Phenyldichloroarsine with Biological Molecules

Descriptive Note:

Final technical rept. 1 May 1985-1 May 1986

Corporate Author:

LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Report Date:

1986-08-01

Pagination or Media Count:

26.0

Abstract:

Carbon 14 -Phenyldichloroarsine PDA was used to study the binding of PDA to erythrocytes and stroma-free hemoglobin. Natural abundance Carbon 13- nuclear magnetic resonance spectroscopy Carbon 13-NMR was used to study the binding of DPA to glutathione, meso-2,3-dimercaptossuccinic acid DMSA, and British anti-Lewisite BAL. The results clearly show that PDA penetrates the red cell and is contained within. Apparently hemoglobin is not the internal sulfhydryl-containing species that holds the DPA, glutathione appears to be a better candidate. Carbon 13-NMR is a promising tool for investigating DPA complexes.

Subject Categories:

  • Biochemistry
  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE