Accession Number:

ADA175248

Title:

Reduced Hemorrhage Tolerance in Hyperthermic Conscious Pigs.

Descriptive Note:

Interim rept.,

Corporate Author:

LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Report Date:

1986-09-01

Pagination or Media Count:

12.0

Abstract:

We evaluated the cardiovascular response to hemorrhage 38.5 mlkg over 60 min in conscious normothermic n8 and hyperthermic 40.4 or - 0.4 C, mean SEM n5 Duroc Swine 18-25 kg hyperthermia was defined as a rectal temperature exceeding the normal range, 39.7 or - 1 C n35. Animals were surgically prepared with a carotid artery catheter splenectomized seven days prior to experiments. Measurements were made at 0, 10, 20, 30, 45, and 60, minutes during hemorrhage and at 15, 30, 60, 120, 180, an 240 minutes after hemorrhage. All eight of the normothermic pigs survived. One of the animals with an elevated temperature died in the course of the hemorrhage and two after hemorrhage P0.035. Before hemorrhage, animals with elevated body temperature had significantly P0.05 increased mean arterial pressures 119 or - 3 vs 99 or - 3 mmHg and heart rates 143 or - 7 vs 112 or - 5 bm compared to animals with normal body temperatures. At the end of hemorrhage there was no difference in mean arterial pressures 48 or - 11 mmHg, N4 for hyperthermic pigs and 48 or - 2 mmHg, n8 for normals. Heart rates at the end of hemorrhage were greater in the hyperthermic 183 or - 26 bm than in the normothermic pigs 146 or - 8 bm. Pigs with elevated body temperature, presumably due to some low grade infection at the catheter exit site, had a reduced tolerance to hemorrhage. Author

Subject Categories:

  • Animal Husbandry and Veterinary Medicine
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE