Accession Number:

ADA175104

Title:

A Comparative Study Regarding the Association of Alpha-2U Globulin with the Nephrotoxic Mechanism of Certain Petroleum-Based Air Force Fuels

Descriptive Note:

Final rept. 1 Sep 1984-31 Aug 1986

Corporate Author:

ILLINOIS UNIV AT URBANA DEPT OF VETERINARY BIOSCIENCES

Personal Author(s):

Report Date:

1986-10-31

Pagination or Media Count:

17.0

Abstract:

Fischer 344 male rats have a dose and time dependent proximal tubular degeneration induced by certain petroleum-based fuels. This degeneration may be associated with a low molecular weight alpha globulin termed alpha-2U globulin . A new method was developed to obtain monospecific immunologic reagents for alpha-2U globulin using diafiltration, anion-exchange and hydroxylapatite chromatography. Rocket immunoelectrophoretic and isoelectric focusing techniques were developed to quantitatively and qualitatively assess changes in alpha-2U globulin after experimental exposure to hydrocarbon compounds. Keywords Nephrotoxicity Alpha-2u globulin Rat urinary protein Petroleum products.

Subject Categories:

  • Toxicology
  • Fuels

Distribution Statement:

APPROVED FOR PUBLIC RELEASE