Accession Number:

ADA172995

Title:

Neurophysiological Bases of Event-Related Potentials.

Descriptive Note:

Annual rept. no. 4, 1 May 85-30 Apr 86,

Corporate Author:

SRI INTERNATIONAL MENLO PARK CA LIFE SCIENCES DIV

Personal Author(s):

• Rebert,Charles S.

Report Date:

1986-08-08

Pagination or Media Count:

66.0

Abstract:

In order to more fully understand the physiological and psychological significance of event-related brain potentials, cortical and subcortical recordings were obtained from monkeys performing an operant conditioning task cued reaction time. During the past year three cynomolgus monkeys were studied following the administration of MPTP, a drug that selectively destroys nigra-striatal dopaminergic neurons in the pars compacta of the substantia nigra. This manipulation indicated the critical role of the nigra-striatal dopamine for task performance enhancement would be to determine if increasing nigra-striatal dopaminergic activity would enhance performance and electrophysiological responsivity. Keywords Subcortical Nuclei Biocybernetics Cognition Reaction Time.

Descriptors:

• *ELECTROENCEPHALOGRAPHY
• *NEUROPHYSIOLOGY
• OPTIMIZATION
• JOBS
• BRAIN
• PERFORMANCE(HUMAN)
• COGNITION
• REACTION TIME
• DOPAMINE
• NUCLEI
• PHARMACOLOGICAL ANTAGONISTS
• CYBERNETICS
• MONKEYS
• ELECTROPHYSIOLOGY
• CEREBRAL CORTEX
• POTENTIAL THEORY
• CONDITIONED RESPONSE

Subject Categories:

• Psychology
• Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE