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Neurophysiological Bases of Event-Related Potentials.
Annual rept. no. 4, 1 May 85-30 Apr 86,
SRI INTERNATIONAL MENLO PARK CA LIFE SCIENCES DIV
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In order to more fully understand the physiological and psychological significance of event-related brain potentials, cortical and subcortical recordings were obtained from monkeys performing an operant conditioning task cued reaction time. During the past year three cynomolgus monkeys were studied following the administration of MPTP, a drug that selectively destroys nigra-striatal dopaminergic neurons in the pars compacta of the substantia nigra. This manipulation indicated the critical role of the nigra-striatal dopamine for task performance enhancement would be to determine if increasing nigra-striatal dopaminergic activity would enhance performance and electrophysiological responsivity. Keywords Subcortical Nuclei Biocybernetics Cognition Reaction Time.
APPROVED FOR PUBLIC RELEASE