Accession Number:

ADA172647

Title:

Dermal, Eye and Oral Toxicological Evaluations. Phase II. Acute Oral LD Determinations of Benzothiazole, Dithiane, and Oxathiane.

Descriptive Note:

Rept. for 27 Dec 84-20 Feb 86,

Corporate Author:

BIOASSAY SYSTEMS CORP WOBURN MA

Personal Author(s):

• Mayhew,Dale A.
• Muni,Indun A.

Report Date:

1986-09-03

Pagination or Media Count:

71.0

Abstract:

Benzothiazole, dithiane, and oxathiane were administered by oral gavage to groups of 5 male and 5 female Fischer 344 albino rats to establish their oral toxicity median lethal dose. The oral median lethal dose LD50 of Benzothiazole was determined to be 493 mgkg for males, 466 mgkg for females, and 479 mgkg for the combined sexes. The oral LD50 of Dithiane was determined to be 3,680 mgkg for males, 2,768 mgkg for females, and 3,473 mgkg for the combined sexes. The oral LD50 of Oxathiane was determined to be 3,328 mgkg for males, 3,123 mgkg for the combined sexes. The oral LD50 of Oxathiane for females was estimated to be approximately 3,000 mgkg.

Descriptors:

• *TOXICOLOGY
• *BENZENE COMPOUNDS
• *ORGANIC SULFUR COMPOUNDS
• *THIAZOLES
• RATS
• TOXICITY
• EYE
• SKIN(ANATOMY)
• LETHAL DOSAGE
• ORAL DOSAGE
• IRRITATION

Subject Categories:

• Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE