Accession Number:

ADA172279

Title:

Tendon Fibroplasia Induction by Exogenous Electrical Fields.

Descriptive Note:

Annual rept. 1 Aug 85-31 Jul 86,

Corporate Author:

MEDICAL COLL OF VIRGINIA RICHMOND DEPT OF PHYSIOLOGY AND BIOPHYSICS

Personal Author(s):

• Cleary,Stephen F.
• Liu,Li-Ming
• Diegelmann,Robert

Report Date:

1986-08-10

Pagination or Media Count:

8.0

Abstract:

A parametric study is being undertaken of the effects of extra low frequency ELF conductive electric fields on chicken tendon explant fibroplasia, collagen synthesis and oriented migration. Independent variables are pulse repetition rate, pulse duration, peak current density or electric field strength, explant orientation with respect to E field and donor chicken age. ELF pulsed electric fields with average current densities in the range of 0.18 to 5.7 micro Asq cm induced statistically significant alternations in fibroblast proliferation with a windowed response of peak stimulation of proliferation in the range of 0.4 to micro Asq cm, and suppression at higher current densities.

Descriptors:

• *ELECTRIC FIELDS
• *FIBROBLASTS
• *ELECTROPHYSIOLOGY
• *TENDONS
• PEAK VALUES
• STIMULATION(GENERAL)
• REPETITION RATE
• CONDUCTIVITY
• SYNTHESIS
• CURRENT DENSITY
• PEAK POWER
• PULSE RATE
• PULSES
• MIGRATION
• ELECTRIC CURRENT
• CHICKENS
• LOW FREQUENCY
• FIELD INTENSITY
• COLLAGEN
• EXTREMELY LOW FREQUENCY

Subject Categories:

• Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE