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Periodontal Wound Healing Responses to Varying Oxygen Concentrations and Atmospheric Pressures.
AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH
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Studies using hyperbaric oxygen have shown accelerated connective tissue proliferation in wounded and compromised tissues. The purpose of this thesis was to determine if increased postoperative oxygen andor increased atmospheric pressure could enhance connective tissue healing responses following periodontal surgery. To test oxygen effects on a standardized periodontal wound, gingival wedge excisions were accomplished mesial to the maxillary right first molars of 205 Sprague-Dawley rats. Connective tissue healing above a reference notch on the mesial root was assessed by two-way analysis of variance. Results confirmed previous studies which showed limited tissue coadaptation before one week. Controls failed to show healing comparable to experimental animals until the end of two weeks. This study demonstrated that connective tissue healing can be initially enhanced by using hyperbaric pressure at 2.4 atmospheres with either 20 or 100 oxygen and to a lesser extent by 100 normobaric oxygen. However, early connective tissue adaptation does not necessarily imply eventual attachment as slow epithelial downgrowth progressively displaced the connective tissue adjacent to the root.
APPROVED FOR PUBLIC RELEASE