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Toxicologic and Analytical Studies with T-2 and Related Trichothecene Mycotoxins
Annual progress rept. no. 2, 11 Mar 1983-15 Aug 1984
ILLINOIS UNIV AT URBANA COLL OF VETERINARY MEDICINE
Pagination or Media Count:
Swine have been used as a model for assessing the effects of exposure to T-2 toxin. Acute T-2 toxicosis is a cardiovascular shock syndrome characterized by reductions in cardiac output and blood pressure, and increased plasma concentrations of epinephrine, norepinephrine, thromboxane B2, 6-keto-PGF 1 alpha, and lactate. An initial leukocytosis is followed by a leukopenia. Serum bound calcium concentrations decrease while magnesium, phosphorus and potassium increase. Blood flow to the heart, brain, kidneys, spleen and stomach decreases, while blood flow to the adrenal glands, liver and intestines increases. Topical application of T-2 toxin in swine produces a severe necrotizing dermatitis with the healing process beginning on day 7. Morphologic changes in internal organs are minimal. Responses of purified peripheral blood lymphocytes to the T-cell mitogens, phytohemagglutinin and concanavalin A, are decreased between days 20 and 31 after dosing. Neutrophilia and fever are apparent during the first 2 weeks of exposure. Body weights of treated pigs decrease after the first week. There are significant reductions in serum albumin, alkaline phosphatase and glucose but increases in serum globulin in the first 2 weeks. Sublethal intravenous injection of T-2 toxin produce heart and pancreatic lesions in addition to the well-documented radiometric lesions. Numerous potential therapeutic agents have been tested for efficacy against T-2 toxicosis. Key words Metabolism Pathophysiology Immunopathology Hematology Serum biochemistry Fusarium.
APPROVED FOR PUBLIC RELEASE