Accession Number:

ADA172207

Title:

Toxicologic and Analytical Studies with T-2 and Related Trichothecene Mycotoxins

Descriptive Note:

Annual rept. no. 1,

Corporate Author:

ILLINOIS UNIV AT URBANA COLL OF VETERINARY MEDICINE

Report Date:

1983-03-01

Pagination or Media Count:

83.0

Abstract:

T-2 toxin intravascularly produced a cardiovascular shock syndrome in swine characterized by early decreased cardiac output and urine production, and a later decline in blood pressure. Core body temperature remained normal but extremities became cold. Hemoglobin of arterial blood was oxygen saturated in spite of cutaneous cyanosis. Severe metabolic acidosis developed. There were marked elevations in plasma 6-keto-PGF1alpha, and thromboxane B2 metabolites of vasoactive prostanoids, and transitory elevations in epinephrine and norepinephrine. Serum calcium and glucose declined while phosphorus, BUN, magnesium and potassium increased. Pathologic changes included lymphoid necrosis, gastroenteric mucosal hyperemia, enterocyte necrosis, focal myocardial degeneration and endocardial hemorrhage. A gas chromatographic-electron capture detection method for the analysis of T-2 toxin and metabolites in plasma and urine has been developed. Isolates of Fusarium have been obtained and are being screened for trichothecene profiles. In vitro incubations of T-2 toxin with swine liver microsomes has resulted in the production of several new metabolites.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE