Accession Number:

ADA172172

Title:

Comparative Studies of the Short-Term Toxicity of the Hydraulic Fluids MIL-H-19457C, MIL-H-19457B, and MIL-H-22072B.

Descriptive Note:

Technical rept. Dec 81-May 85,

Corporate Author:

CALIFORNIA UNIV DAYTON OH

Personal Author(s):

• Gaworski,C. L.
• Kinkead,E. R.
• Horton,J. R.
• Bashe,W. J.
• Einhaus,E. L.

Report Date:

1986-07-09

Pagination or Media Count:

40.0

Abstract:

Acute toxicity studies including eye and skin irritation, skin sensitization, single dose oral, single dose intraperitoneal, 4-hour aerosol inhalation, single dose dermal, and 21-day repeated aerosol inhalation were conducted with the hydraulic fluids MIL-H-19457C, MIl-H-19457B and MIl-H-22072B. The first two hydraulic fluids are triarylphosphate ester-based materials, while the third is glycol based. MIL-H-19457C and MIl-H-19457B were also tested for neurotoxic potential with a repeated dose screening assay in chickens. None of the three hydraulic fluids produced eye or skin irritation in rabbits. Guinea pig sensitization tests were also negative for all three fluids. Single oral doses of 5 mLkg of any of the materials failed to produce mortality in male or female Sprague-Dawley rats. Diarrhea and weight loss were seen in the rats given either MIL-H-19457C or MIl-H-19457B. These effects were not seen in the rats dosed with MIL-H-22072B. Single dose intraperitoneal LD50 values were also determined.

Descriptors:

• *TOXICITY
• *HYDRAULIC FLUIDS
• AEROSOLS
• RATS
• MATERIALS
• SHORT RANGE(TIME)
• DIARRHEA
• DOSAGE
• EYE
• ESTERS
• CHICKENS
• WEIGHT REDUCTION
• SKIN(ANATOMY)
• FEMALES
• ORAL DOSAGE
• BIOASSAY
• RABBITS
• INHALATION
• SENSITIZING
• IRRITATION

Subject Categories:

• Toxicology
• Lubricants and Hydraulic Fluids

Distribution Statement:

APPROVED FOR PUBLIC RELEASE