Accession Number:

ADA172030

Title:

Exact Significance Testing with Biased Coin Randomization.

Descriptive Note:

Technical rept.,

Corporate Author:

FLORIDA STATE UNIV TALLAHASSEE DEPT OF STATISTICS

Personal Author(s):

• Hollander,Myles
• Pena,Edsel

Report Date:

1986-06-01

Pagination or Media Count:

19.0

Abstract:

For a clinical trial where two treatments have been assigned sequentially to patients via Efrons 1971 biased coin design, a recursion procedure is derived for obtaining the exact randomization distribution of a class of test statistics. This enables one to perform exact significance tests of the hypothesis of no treatment difference. The randomization distribution of the statistic is conditional on the imbalance of the treatment allocation. It is illustrated that if the analysis is performed as if complete randomization was used, conservative and anticonservative errors can be incurred. The applicability of the test to censored data is also discussed. Author

Descriptors:

• *STATISTICAL TESTS
• *CLINICAL MEDICINE
• COMPUTERIZED SIMULATION
• COMPUTATIONS
• RANDOM VARIABLES
• PROBABILITY
• FORTRAN
• STATISTICAL DISTRIBUTIONS
• PATIENTS
• BIAS
• MARKOV PROCESSES

Subject Categories:

• Medicine and Medical Research
• Statistics and Probability

Distribution Statement:

APPROVED FOR PUBLIC RELEASE