Comparison of PFDA (Perfluoro-n-Decanoic Acid) and TCDD on Heart Membranes.
Final rept. 1 May 82-14 Aug 85,
WRIGHT STATE UNIV DAYTON OH SCHOOL OF MEDICINE
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Our initial observations of a reduced responsiveness to adrenergic stimulation of hearts from Perfluoro-n-decanoic acid PFDA-treated rats has been examined in terms of functional components of the myocardial membrane. The reduced responsiveness can be explained in part by a decrease in the number of cell surface beta adrenergic receptors. An early and dramatic fall in serum levels of thyroid hormones was observed. Because much of the loss of adrenergic responsiveness can be explained by the effects of PFDA on thyroid hormones we concentrated our research on the antithyroid actions of PFDA. The most significant results of this research was the observation reported in detail herein that thyroxine supplementation could prevent the hypophasia characteristic of PFDA treatment without effecting the body wasting syndrome and hypothermia. The mechanism of these paradoxical actions remains to be determined.