The Function and Structure of Peripheral Nerves Following Cutaneous Burns.
Annual summary rept. 16 Mar 82-14 Jun 83,
WASHINGTON UNIV SEATTLE SCHOOL OF MEDICINE
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Using a radio frequency generator several experimental models have been developed which permit study of the effects of heat on the electrophysiological function, the biochemistry and the morphology of the rat sciatic nerve and its major branches. Experiments are carried out both in vivo and in vitro. The results to date indicate that motor fibers are more resistant to a given heat load in vitro than are sensory ones of similar diameter. With respect to fiber size, the A-delta groups appear to be more sensitive than are the A-alpha fibers. C-fiber heat sensitivity is apparently intermediate between the A-delpha and A-alpha. Biochemical analyses of injured nerves indicate striking changes both in the myelin and soluble protein fractions. The time course of neural edema formation and resolution and of endoneurial vascular permeability change is being correlated with the biochemical, structural and electrophysiological abnormalities observed. Little is known about the etiology and pathogenesis of the peripheral neuropathies which become evident clinically in a significant proportion 20-30 of patients with major thermal injuries. This project studies the effects, direct or indirect, of thermal injury on the electrophysiological function and associated biochemical and morphological alterations of the sciatic nerve that attend thermal injury in rats.
- Anatomy and Physiology