Scintigraphy for Pulmonary Capillary Protein Leak
Rept. no. 2 (Annual) 1 Jul 1982-15 May 1983
MEDICAL COLL OF VIRGINIA RICHMOND DEPTOF SURGERY
Pagination or Media Count:
Pulmonary gamma scintigraphy is a rapid, non-invasive technique for measuring a pulmonary capillary protein leak in ARDS. In these studies, the method demonstrated that the acute anesthetized lung lymph fistula sheep model was associated with a significant pulmonary capillary protein leak. No leak was demonstrated in dogs following either large doses of Intralipid, sodium morrhuate or endotoxin. The protein leak following oleic acid could not be prevented with methylprednisolone 30 mgkg, ibuprofen 12.5 mgkg, MK-447 4 mgkg, or calcium gluconate 140 mgkg. A significant and persistent leak followed the instillation of 0.1 hydrochloric acid into the trachea of dogs. This was not altered with pre-treatment with 30 mgkg methylprednisolone or 12.5 mgkg ibuprofen. Prostacyclin PGI sub2 infusion at 0.3 mcgkgmin increased the rate of leak, as measured by the SI, by 50. A significant SI was noted in pigs following the intravenous infusion of Pseudomonas 1,000,000,000 orgskg min. Studies will be undertaken to investigate the ability of various agents methylprednisolene, ibuprofen, PGI sub2 to alter the SI following Pseudmonas infusions in the pig. Atelectasis was produced in 5 dogs by inflation of a balloon in the right main bronchus and repeat SIs were obtained. Altelectasis did not produce an increased SI. These studies will be compared to a group of dogs in which a right lobar pneumococcal pneumonia will be produced..
- Medicine and Medical Research