Accession Number:

ADA171718

Title:

Scintigraphy for Pulmonary Capillary Protein Leak

Descriptive Note:

Annual summary rept. no. 1, 1 Oct 1981-1 Jul 1982

Corporate Author:

MEDICAL COLL OF VIRGINIA RICHMOND DEPTOF SURGERY

Report Date:

1982-09-01

Pagination or Media Count:

29.0

Abstract:

Pulmonary gamma scintigraphy is a rapid, non-invasive technique for measuring a pulmonary capillary protein leak in ARDS. In these studies, the method demonstrated that the acute anesthetized lung lymph fistula sheep model was associated with a significant pulmonary capillary protein leak. No leak was demonstrated in dogs following either large doses of Intralipid, sodium morrhuate or endotoxin. The protein leak following oleic acid could not be prevented with methylprednisolone 30 mgkg, ibuprofen 12.5 mgkg MK-447 4 mgkg, or calcium gluconate 140 mgkg. A significant and persistent leak followed the installation of 0.1 hydrochloric acid into the trachea of dogs. Additional studies relating to these issues are in progress.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE