Accession Number:

ADA171602

Title:

HMX: 13 Week Toxicity Study in Mice by Dietary Administration

Descriptive Note:

Final rept. Jan-Nov 1981

Corporate Author:

INVERESK RESEARCH INTERNATIONAL LTD MUSSELBURGH (UNITED KINGDOM)

Personal Author(s):

• Everett, D. J.
• Maddock, S. M.

Report Date:

1985-07-31

Pagination or Media Count:

324.0

Abstract:

Mice were fed diets containing HMX for 13 weeks. Dose levels for males were 0, 5, 12, 30, 75 or 200 mg HMXkgday. Female mice received 0, 10, 30, 90, 250 or 750 mg HMXkgday. Mortalities attributable to HMX at 200 mg HMX kgday amongst males and at 250 and 750 mg HMXkgday amongst females. Occasional deaths at lower dose levels were of uncertain aetiology. No marked effects on body weight were noted although food consumption was reduced amongst higher dosed males and females. There were slight but equivocal changes in haematological and clinical chemical observations. Neither gross autopsy nor histopathology revealed any findings likely to be associated with the administration of HMX.

Descriptors:

• *DIET
• *TOXICOLOGY
• *HMX
• TOXICITY
• EXPLOSIVES
• REDUCTION
• BODY WEIGHT
• BIOASSAY
• UNITED KINGDOM
• HEMATOLOGY
• FOOD CONSUMPTION
• HISTOPATHOLOGY
• URINE
• DOSAGE
• MICE
• MORTALITY RATE

Subject Categories:

• Toxicology
• Ammunition and Explosives

Distribution Statement:

APPROVED FOR PUBLIC RELEASE