HMX: 13 Week Toxicity Study in Rats by Dietary Administration
Final rept. Dec 1980-May 1981
INVERESK RESEARCH INTERNATIONAL LTD MUSSELBURGH (UNITED KINGDOM)
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Rats were fed diets containing HMX for 13 weeks. Dose levels for males were 0, 50, 150, 450, 1350 or 4000 mg HMXkgday. Female rats received 1, 50, 115, 270, 620 or 1500 mg HMXkgday. No deaths or clinical signs occurred attributable to dosing with HMX. Reduced body weight gains and food consumptions were observed, more so at higher dose levels. Haematological and clinical chemical observations were made only on top dose and control animals. There were slight but consistent reductions in Hb, PCV and possibly RBC. AP activity was increased and there was evidence of methaemoglobinaemia but other clinical chemical changes were inconsistent. There were no changes at gross autopsy. Histopathology revealed enlarged centrilobular cells with pale nuclei and dark cytoplasm in the livers of males dosed at 150 mg HMXkgday and above. Females given 270 mg HMXkgday and above showed changes in renal tubules. The renal effect was less apparent in males.
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