Accession Number:

ADA171597

Title:

HMX: 14 Day Toxicity Study in Rats by Dietary Administration

Descriptive Note:

Final rept. Oct-Nov 1980

Corporate Author:

INVERESK RESEARCH INTERNATIONAL LTD MUSSELBURGH (UNITED KINGDOM)

Personal Author(s):

• Greenough, R. J.
• McDonald, P.

Report Date:

1985-07-30

Pagination or Media Count:

86.0

Abstract:

Male and female rats were dosed via the diet for 14 days with HMX in order to select dose levels for a 13 week study. Concentrations were selected to give doses of 0, 100, 1000, 3000 and 9000 mg HMXkgday. Deaths occurred in males at 9000 mg HMXkgday and in females at 1000 mg HMXkgday and above. There were substantial effects on food intake and upon body weight. Histopathological examination revealed centrilobular toxic degeneration in the lives of male and female rats. There was also hepatocyte hyperplasia, increased cyto plasmic eosinophilia in the liver and lymphocytic depletion in the spleen and thymus.

Descriptors:

• *TOXICOLOGY
• *HMX
• RATS
• TOXICITY
• EXPLOSIVES
• DOSAGE
• LIVER
• DEATH
• THYMUS
• FOOD CONSUMPTION
• DIET
• LYMPHOCYTES
• BODY WEIGHT
• HISTOPATHOLOGY
• SPLEEN

Subject Categories:

• Toxicology
• Ammunition and Explosives

Distribution Statement:

APPROVED FOR PUBLIC RELEASE