HMX: 14 Day Toxicity in Mice by Dietary Administration
Final rept. Oct-Nov 1980
INVERESK RESEARCH INTERNATIONAL LTD MUSSELBURGH (UNITED KINGDOM)
Pagination or Media Count:
Male and female mice were fed diets containing up to 500 mg HMXkg day for 14 days with the object of selecting dose levels for a 13 week study. Deaths occurred in males at 300 mgkg and above and in females at 800 mgkg and above. Clinical signs included hyperkinesia. Histopathology of premature decedents revealed some hepatocellular hyperplasia, cytoplasmic eosinophilia and cellular depletion of splenic red and white pulp. Cause of death was not determined.
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