HMX: Analysis of Dosing Formulations Used in Acute, Sub-Acute and Sub-Chronic Toxicity Studies.
Final rept. Jul 80-Apr 81,
INVERESK RESEARCH INTERNATIONAL LTD MUSSELBURGH (SCOTLAND)
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HMX can be detected in dosing solutions and in diets prepared for toxicity studies by reverse phase HPLC. Dietary preparations were stable for at least 21 days when stored in ambient conditions in the dark. Almost all the dosing solutions and diets prepared for a range of studies were shown to contain dose to the desired concentrations of HMX. There was, however, the possibility of an interchange between 2 groups on one occasion on the 13 week rat study.
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