Accession Number:

ADA171583

Title:

Fundamental Studies in the Molecular Basis of Laser Induced Retinal Damage.

Descriptive Note:

Annual rept. Sep 82-Aug 83,

Corporate Author:

CORNELL UNIV ITHACA NY

Personal Author(s):

Report Date:

1983-09-01

Pagination or Media Count:

41.0

Abstract:

This research has led to major discoveries in two general areas. First, we have been able to show that there are a series of anionic activators of visual cells. These anionic activators turn on, in the dark, the enzymatic processes which are usually stimulated by light. Among these anionic activators is fluoride, the important additive in dental care. It is possible that our discovery of anionic activators will allow us to modulate visual sensitivity and excitation. A second major advance during the past year has been the development of a staining method which allows the direct observation with light microscopy of actin filaments in rod outer segments. This discovery will now allow us to view these important actin filaments in live cells under physiologically relevant experimental conditions. It will also allow for the development of new methods to probe pathological and damaged conditions in visual photoreceptor cells. The above discoveries will now be described in two separate sections. The first entitled Anionic Activators of Photoreceptor Cells in the Dark and the second entitled Visualization of Actin in Photoreceptor Cells by Light Microscopy .

Subject Categories:

  • Biochemistry
  • Radiobiology
  • Lasers and Masers

Distribution Statement:

APPROVED FOR PUBLIC RELEASE