Accession Number:

ADA171380

Title:

Study of the Pathogenicity of a Eromonas Hydrophila for Man

Descriptive Note:

Annual rept. 1 Feb 1983-14 Aug 1984

Corporate Author:

TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON

Personal Author(s):

• DuPont, Herbert L.

Report Date:

1983-08-15

Pagination or Media Count:

18.0

Abstract:

A pool of volunteers from the Houston Community were attracted to our Institution for efficient study in the Hospital. Three strains of A. hydrophila were selected for study in volunteers based on recovers from patients in well defined studies laboratory studies of the presence of virulence propeties Recovery from selective media and antibiorgrams. The tests strains were fed to 5 groups of volunteers in doses ranging from 10,000 to 10 million viable cells. Transient excretion of the test strain rarely occured in any group and, despite the passage of several soft and rare watery stools by four volunteers, frank illness did not develop. We are currently looking at the development of humoral antibodies in the volunteers and are feeding the test strains in a dose of 100 million viable cells.

Descriptors:

• *ENTEROPATHOGENS
• *GRAM NEGATIVE BACTERIA
• HUMANS
• VOLUNTEERS
• DIARRHEA
• ENTEROTOXINS
• STRAINS(BIOLOGY)
• DOSAGE
• VIRULENCE
• BACTERIAL TOXINS

Subject Categories:

• Medicine and Medical Research
• Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE