Host Defense Against Opportunist Microorganisms Following Trauma
Annual summary rept. no. 7, 1 Sep 1982-31 May 1983
CHRIST HOSPITAL CINCINNATI OH INST OF MEDICAL RESEARCH
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Circulating inhibitors of polymorphonuclear neutrophil, lymphocyte, and alternative complement pathway function that are produced following burn injury and are presumed to play an important role in lowering host resistance were studied in this investigation. Preliminary evidence suggesting that these inhibitory factors represent one molecular species was not confirmed. Infection was shown to be a major stimulus in induction of the inhibitors of neutrophil and complement function. This latter inhibitor was found to exert its effect by interfering with cleavage of C3 by alternative pathway convertases.
- Medicine and Medical Research